Description
Recombinant full-length human STK19 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The STK19 gene accession number is NM_004197.
STK19 is a member of the serine/threonine kinase family that shows a manganese-dependent protein kinase activity and phosphorylates alpha-casein at ser/thr residues and histone at ser residues. STK19 contains a positively charged putative nuclear localization signal, multiple potential phosphorylation sites, 2 amidation sites, 9 potential N-myristoylation sites, and no N-glycosylation sites. STK19 has been shown to localize predominantly in the nucleus (1). The phosphorylation of STK19 is thought to be involved in transcriptional regulation. STK19 localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 (2)